Episode 8: Cannabis in Chemo, Cancer, and Seizures, OH MY!
Dave and Lebaron Agostini discuss Cannabis as a treatment for seizures, the alleviating of chemotherapy symptoms, and the potential of cannibas as a treatment for cancer! We take an in depth look at the the biological pathways for each after a brief history lesson on the legality of the substance in the US. We explain the biomedical story behind cannabis and cancer, and describe why there is no cure for cancer.
In the history lesson, we give the laws behind the stigmas of cannabis and the consequences of the schedule 1 drug status that arose from the previous laws. We go into details about targeting the receptor by Epidiolex for the alleviation of seizures in Dravet Syndrome and Lennox-Gastaut Syndrome. Finally, discuss the downstream protein pathway from the CB1 receptor that includes p8, TRIB3, Akt, mTOR, and BAD. We go into details about their anti-tumorgenic properties when this pathway is activated. Conversely, the CB2 receptor when targeted is pro-tumorgenic due to its location on B and T cells.